Federica mastroiacovo Fiona Limanaqi, 1, † Francesca Biagioni, 2, † Federica Mastroiacovo, 2 Maico Polzella, 3 Gloria Lazzeri, 1, * and Francesco Fornai 1, 2, * Fiona Limanaqi 1 Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Roma 55, 56126 Pisa, Italy; ti. Abstract:Orexin-A (OX-A) protects the brain against oxidative stress-mediated ischemic injury. (#) p < 0. Find articles by Federica Mastroiacovo. International retrospective cohort study of neural tube defects in relation to folic acid recommendations: are the recommendations working? BMJ. doi: 10. Introduction. View the profiles of people named Mastroiacovo Federica. , daily for 18 days, administered at 5. Cite. International Journal of Molecular Sciences 2018 July 7. In Figure 1 the outcome following the induction of permanent ischemia following MCA occlusion in C57Black mice is reported. org/10. Da oggi puoi trovare tutte le notizie regionali e nazionali, anche su internet: portale 11573/1702931 - 2024 - Changes in kynurenine metabolites in the gray and white matter of the dorsolateral prefrontal cortex of individuals affected by schizophrenia Federica Mastroiacovo. In rats Jakob Hakon 1 , Miriana J Quattromani 1 , Carin Sjölund 1 , Daniela Talhada 1 , Byungchan Kim 2 , Slavianka Moyanova 3 , Federica Mastroiacovo 3 , Luisa Di Menna 3 , Roger Olsson 4 , Elisabet Englund 5 , Ferdinando Nicoletti 3 6 , Karsten Ruscher 1 , Adam Q Bauer 2 , Tadeusz Wieloch 1 Loop is the open research network that increases the discoverability and impact of researchers and their work. autophagy vacuoles 11573/1702931 - 2024 - Changes in kynurenine metabolites in the gray and white matter of the dorsolateral prefrontal cortex of individuals affected by schizophrenia Int. Federica Mastroiacovo; Francesca Biagioni; Paola Lenzi [] Francesco Fornai; The heat shock protein (HSP) 70 is considered the main hallmark in preclinical studies to stain the peri-infarct Mastroiacovo F, Di Pietro P, Traﬁcante A, Bozza G, Niehrs C, Battaglia G, Bruno V, Fornai F, Volpe M, Rubattu S and Nicoletti F (2018) Dickkopf-3 Causes Neuroprotection by Inducing Vascular Endothelial Growth Factor. This suggested that TGF Federica Mastroiacovo ha presentato uno studio sull’uso di farmaci attivati dalla luce per identificare il sito d’azione degli antagonisti dei recettori Federica Mastroiacovo ha presentato uno studio sull’uso di farmaci attivati dalla luce per identificare il sito d’azione degli antagonisti dei recettori mGlu5 nel miglioramento del Create a SciFeed alert for new publications. IRCCS Istituto Neurologico Mediterraneo Neuromed; Domenico Bucci. Author links open overlay panel Filippo Caraci a 1, Giuseppe Battaglia b, Carla Busceti b, Francesca Biagioni b, Federica Mastroiacovo b, Paolo Bosco c, Filippo Drago d, Ferdinando Nicoletti b e, Maria Angela Sortino d 2, Agata Copani a f 2. Join Facebook to connect with Mastroiacovo Federica and others you may know. The hypothesis that activation of mGlu2 receptors is detrimental in the post-ischemic phase is supported, and the use of m Glu2 receptor antagonists in the experimental treatment of brain ischemia is supported. v. Download full-text PDF Read full-text. Busceti 1, Larisa Ryskalin 2, Rosangela Ferese 1, Domenico Bucci 1, Alessandro Frati 1,3, Ferdinando Nicoletti Reference: “Inhibiting metabotropic glutamate receptor 5 after stroke restores brain function and connectivity” by Jakob Hakon, Miriana J Quattromani, Carin Sjölund, Daniela Talhada, Byungchan Kim, Slavianka Jakob Hakon, Miriana J Quattromani, Carin Sjölund, Daniela Talhada, Bungchan Kim, Slavianka Moyanova, Federica Mastroiacovo, Luisa Di Menna, Roger Olsson, Elisabet Federica Mastroiacovo; Francesca Biagioni; Paola Lenzi; Gloria Lazzeri; Francesco Fornai; The brain area which surrounds the frankly ischemic region is named the area penumbra. Federica Mastroiacovo 1 Manuela Zinni 2 Giada Mascio 1 Valeria Bruno 1,3 Giuseppe Battaglia 1,3 Julien Pansiot 2 Tiziana Imbriglio 1 Jerome Mairesse 2,4 Olivier Baud 2,4,5 Ferdinando Nicoletti 1,3 * 1 Department of Molecular Pathology, I. A) Dkk-1 and -catenin expression in the ischemic penumbra 3 days (3 d) after Et-1 infusion in rats treated with either saline or LiCl (1 mEq/kg every 12 h for 7 days before the onset of ischemia Francesca Biagioni,Federica Mastroiacovo,Paola Lenzi,Stefano Puglisi-Allegra,Carla L Busceti,Larisa Ryskalin,Rosangela Ferese,Domenico Bucci,Alessandro Frati,Ferdinando Nicoletti,Francesco Fornai PubMed 34638703 Loop is the open research network that increases the discoverability and impact of researchers and their work. Phased Treatment Strategies for Cerebral Il Quotidiano del Molise è una testata giornalistica a carattere regionale, in edicola da ben 15 anni. itneduts@iqanamil. 1 Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Neuromed, 86077 Pozzilli, Italy . ORIGINAL RESEARCH published: 11 September 2018 doi: 10. 38336. Kortenska Federica Mastroiacovo; Francesca Biagioni; Paola Lenzi; Gloria Lazzeri; Francesco Fornai; The brain area which surrounds the frankly ischemic region is named the area penumbra. Share. Dr. Loop enables you to stay up-to-date with the latest discoveries and news, connect with researchers and form new collaborations. NeuralEng. 1, Milena Cannella. Cell. Andrea Guala, Email: Taccardi R, Annona C, Ghiotti P, Mastroiacovo P, Tamburlini G, Gruppo di Lavoro Conoscere per Prevenire [Periconceptional supplementation with folic acid for the primary prevention of congenital malformations] Pediatr Med Chir. org) and phone number at RocketReach. Read online or download for free from Z-Library the Book: Abnormal Hippocampal Melatoninergic System: A Potential Link between Absence Epilepsy and, Autor: Moyanova PDF | The heat shock protein (HSP) 70 is considered the main hallmark in preclinical studies to stain the peri-infarct region defined area penumbra in | Find, read and cite all the research you Pierpaolo Mastroiacovo 1, Roy Miodini Nilsen 1,2, Emanuele Leoncini 1, Paolo Gastaldi 3, Valentina Allegri 4, Arianna Boiani 5, Francesca Faravelli 6, Federica Ferrazzoli 7, Andrea Guala 8, Valeria Madrigali 9 & Federica Mastroiacovo; Manuela Zinni; Giada Mascio 2007) and ischemia (Mastroiacovo et al. BackgroundTo examine whether metabotropic molecules Article Stoichiometric Analysis of Shifting in Subcellular Compartmentalization of HSP70 within Ischemic Penumbra Federica Mastroiacovo 1,†, Francesca Federica Mastroiacovo ha presentato uno studio sull’uso di farmaci attivati dalla luce per identificare il sito d’azione degli antagonisti dei recettori mGlu5 nel miglioramento del recupero funzionale post-ictus. Show more. Busceti 2 Federica Mastroiacovo 2 Ferdinando Nicoletti 2 Stefano Puglisi-Allegra 2 Francesco Fornai 1,2* Mastroiacovo, Nicoletti, Puglisi-Allegra and Fornai. Show all 7 authors Hide. 1. Multidisciplinary Digital Publishing Institute Loop is the open research network that increases the discoverability and impact of researchers and their work. c. } and Tadeusz Wieloch", Get Federica Mastroiacovo's email address (f*****@elis. Department of Human Physiology and Pharmacology, University of Rome La Sapienza, 00185, Rome, Italy Wide experimental evidence has been provided in the last decade concerning the neuroprotective effects of phytochemicals in a variety of neurodegenerative disorders. mdpi. , 1981; Mastroiacovo et al. 2. We have recently shown that pharmacological blockade of mGlu2 metabotropic glutamate receptors protects vulnerable neurons in the 4-vessel occlusion model We examined the influence of type 4 metabotropic glutamate (mGlu4) receptors on ischemic brain damage using the permanent middle cerebral artery occlusion (MCAO) model in mice and the endothelin-1 Mastroiacovo F, Di Pietro P, Traﬁcante A, Bozza G, Niehrs C, Battaglia G, Bruno V, Fornai F, Volpe M, Rubattu S and Nicoletti F (2018) Dickkopf-3 Causes Neuroprotection by Inducing Vascular Endothelial Growth Factor. Paola Lenzi. Molecules (Basel, Switzerland), 27(10) (2022-05-29) The brain area which surrounds the frankly ischemic region is named the area penumbra. Contributors: Federica Mastroiacovo; Francesca Biagioni; Paola Lenzi; Gloria Lazzeri; Michela Ferrucci; Stefano Puglisi-Allegra; Alessandro Frati; Ferdinando Nicoletti; Francesco Fornai Show more detail Federica Ferrazzoli, Email: moc. Jakob Hakon, Miriana J Quattromani, Carin Sjölund, Daniela Talhada, Byungchan Kim, Slavianka Moyanova, Federica Mastroiacovo, Luisa Di Menna, Roger Olsson, Elisabet Englund, Ferdinando Nicoletti, Karsten Ruscher, Adam Q Bauer, Tadeusz Wieloch, Inhibiting metabotropic glutamate receptor 5 after stroke restores brain function and Loop is the open research network that increases the discoverability and impact of researchers and their work. Get 5 free searches. Slavianka G Moyanova, 1, 5 Federica Mastroiacovo, 2, 5 Lidia V Kortenska, 1 Rumiana G Mitreva, 1 Erminia Fardone, 2 Ines Santolini, 2 Mónica Sobrado, 3 Giuseppe Battaglia, 2 Valeria Bruno, 2, 4 and ischemic damage was assessed 3 days later (Moyanova et al, 2007; Mastroiacovo et al, 2009). A number of data collected over the last few decades define the ischemic penumbra as a critical region identified by magnetic resonance imaging (MRI). (A) Nissl staining in 10 μm coronal mouse brain sections collected every 320 μm along the rostro-caudal extension of the ischemic lesion in wild-type and Dkk3 knockout mice 1 day after middle cerebral artery occlusion (MCAO). Generally, the neuroprotective effects of bioactive compounds belonging to different phytochemical classes are attributed to antioxidant, anti-aggregation, and anti-inflammatory activity along with the Washington University School of Medicine Digital Commons@Becker 2020-Current year OA Pubs Open Access Publications 1-4-2024 Inhibiting metabotropic glutamate receptor 5 after stroke restores molecules Article Stoichiometric Analysis of Shifting in Subcellular Compartmentalization of HSP70 within Ischemic Penumbra Federica Mastroiacovo 1,†, Francesca Biagioni 1,†, Paola Lenzi 2 Cerebral palsy (CP) is still the most common cause of disability developing in infancy. Oxidative stress arises from a decrease of antioxidant defense and a concomitant increase in the levels of reactive oxygen species (ROS) and lipid peroxidation 11573/1702931 - 2024 - Changes in kynurenine metabolites in the gray and white matter of the dorsolateral prefrontal cortex of individuals affected by schizophrenia International Journal of Molecular Sciences Article The Autophagy-Related Organelle Autophagoproteasome Is Suppressed within Ischemic Penumbra Francesca Biagioni 1,†, Federica Mastroiacovo 1,†, Paola Lenzi 2,†, Stefano Puglisi-Allegra 1, Carla L. by Carla Letizia Busceti, Luisa Di Menna, Franca Bianchi, Federica Mastroiacovo, Paola Di Pietro, Anna Traficante, Giovanna Bozza, Christof Niehrs, Giuseppe Battaglia, Valeria Bruno, Francesco Fornai, Massimo Volpe, Speranza Rubattu, Ferdinando Nicoletti. The drug reduced the infarct volume by How to say Federica Mastroiacovo in English? Pronunciation of Federica Mastroiacovo with 1 audio pronunciation and more for Federica Mastroiacovo. Questo approccio innovativo potrebbe aprire nuove strade per migliorare il recupero dei pazienti colpiti da ictus. Marta Motolese 1 , Federica Mastroiacovo 1 , Milena Cannella 1 , Domenico Bucci 1 , Anderson Gaglione 1 , Barbara Riozzi 1 , Robert Lütjens 2 , Sonia M Poli 2 , Sylvain Celanire 2 3 , Valeria Bruno 1 4 , Giuseppe Battaglia 1 , Ferdinando Nicoletti 5 6 Federica Mastroiacovo. Since the endocannabinoid 2-arachidonoylglycerol (2-AG) and cannabinoid type-1 (CB1) receptors were previously shown to mediate some of the effects of OX-A exerted through the orexin-1 receptor (OX-1R), we investigated the involvement of 2-AG in OX-A-induced The peri-infarct region, which surrounds the irreversible ischemic stroke area is named ischemic penumbra. Molecular Brain (2017) 10:39 DOI 10. 2004; 26 (2):105–111. MOOC. The glymphatic system contributes to the transport of nutrients and signaling molecules into the brain parenchyma meanwhile promoting the clearance of PDF | We have recently shown that pharmacological blockade of mGlu2 metabotropic glutamate receptors protects vulnerable neurons in the 4-vessel | Find, read and cite all the research you need Gianfranco Natale 1* Fiona Limanaqi 1 Carla L. 3389/fncel. Here, we report that the secreted Wnt antagonist, Dickkopf-1 (Dkk-1) is rapidly induced in neurons after induction of focal brain ischemia. Dickkopf-3 Causes Neuroprotection by Inducing Vascular Endothelial Growth Factor. (A) Hippocampal levels of melatonin in Wistar and WAG/Rij rats under basal conditions (Sham), 24 days after surgical removal of the pineal gland (Pin), and after melatonin replacement (10 mg/kg, s. m. Slices were stained with toluidine blue to isolate neurons for transmission electron microscopy (TEM) as shown in (C,D) delineated by a red perimetral line. injection of SB431542, a selective inhibitor of transforming growth factor-beta (TGF-beta) receptor. Orexin-A (OX-A) protects the brain against oxidative stress-mediated ischemic injury. TOPICS. 1186/s13041-017-0319-6. Download scientific diagram | HDAC2 protein levels and Grm2 promoter H3-acetylation in the CA1 region following global ischemia. Orientation. (a) Western blot analysis of HDAC2 in CA1 region at 12 and 24 h The canonical Wnt pathway contributes to the regulation of neuronal survival and homeostasis in the CNS. liamtoh@arrefaciredef. Phased Treatment Strategies for Cerebral “Nel lavoro scientifico – afferma Federica Mastroiacovo, ricercatrice Neuromed – abbiamo dimostrato con strategie genetiche e farmacologiche che l’inibizione del recettore mGlu5 favorisce un significativo recupero del deficit sensomotorio causato dalla patologia”. ipinu. (A) summarizes the cascade of pathogenic events implicated in neurodegeneration. Federica Pro. S. Federica Mastroiacovo; Francesca Biagioni; Paola Lenzi; Gloria Lazzeri; Francesco Fornai; The brain area which surrounds the frankly ischemic region is named the area penumbra. , 2017). Neuromed, Pozzilli, Federica Mastroiacovo. Facebook gives Federica Mastroiacovo, Slavianka Moyanova, Milena Cannella, Anderson Gaglione, Remy Verhaeghe, Giovanna Bozza, Michele Madonna, Marta Motolese, Anna Traficante Biography. 11573/1702931 - 2024 - Changes in kynurenine metabolites in the gray and white matter of the dorsolateral prefrontal cortex of individuals affected by schizophrenia Mastroiacovo et al. Gianfranco Natale 1 , Fiona Limanaqi 1 , Carla L Busceti 2 , Federica Mastroiacovo 2 , Ferdinando Nicoletti 2 , Stefano Puglisi-Allegra 2 , Francesco Fornai 1 2 Affiliations 1 Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). 4-VO in rats causes a selective death of pyramidal neurons in the hippocampal CA1 region, leaving neurons of the CA3 region Slavianka G Moyanova, Federica Mastroiacovo, [], Lidia V Kortenska, Rumiana G Mitreva, Erminia Fardone, Ines Santolini, Mónica Sobrado, Giuseppe Battaglia, Valeria Bruno, Ferdinando Nicoletti, and Richard T Ngomba [email protected] +8-8 View all authors and affiliations. , was generated in collaboration with Marta Motolese, Federica Mastroiacovo, Milena Cannella, Giuseppe Battaglia and Ferdinando Nicoletti of IRCCS Neuromed, Italy. effect of these drugs in animal models of global and focal brain ischemia [7–10]. Environment and energy. Representative semithin and ultrathin slices. Recent evidence suggests that an increased expression of Dickkopf-1 (Dkk-1), a secreted protein that negatively modulates the canonical Wnt pathway, is causally related to processes of neurodegeneration in a number of CNS disorders, including Alzheimer's disease Dickkopf-3 (Dkk3) is protective against ischemic neuronal death. “Nel lavoro scientifico – dice la dottoressa Federica Mastroiacovo – abbiamo dimostrato con strategie genetiche e farmacologiche che l’inibizione del recettore mGlu5 “Nel lavoro scientifico – afferma Federica Mastroiacovo, ricercatrice Neuromed – abbiamo dimostrato con strategie genetiche e farmacologiche che l’inibizione del recettore Here we show that the genetic deletion of mGlu3 receptors amplifies ischemic brain damage and associated neuroinflammation in adult mice. Alessandro FRATI, Professor (Associate) | Cited by 4,069 | of Sapienza University of Rome, Rome (la sapienza) | Read 218 publications | Contact Alessandro FRATI Federica Mastroiacovo et al. IRCCS Istituto Neurologico Mediterraneo Neuromed; Paola Lenzi. The data presented at the 2014 American Neuroscience Meeting, Washington D. ). "Stoichiometric Analysis of Shifting in Subcellular View the profiles of people named Mastroiacovo Federica Maria. R. In this area, most Principal Investigator: Ferdinando Nicoletti | ResearchGate, the professional network for scientists Carla Busceti, Francesca Biagioni, Federica Mastroiacovo, Giuseppe Battaglia, Valeria Bruno & Ferdinando Nicoletti. Front. This term emphasizes the The findings suggest that the mGlu2 receptor is an important player in mechanisms regulating neuronal vulnerability to ischemic damage, and that mGLU2 receptor NAMs are potential candidates in the experimental treatments of disorders characterized by brain hypoperfusion, such as hypovolemic shock and cardiac arrest. This corresponds to a region where ischemic infarct is detectable as early as 2–3 h after MCA occlusion, and reaches its maximal size at 24 h. This person is not on ResearchGate, or hasn't claimed this research yet. (2017) mGluR3 Pro-survival Corti et al. In this area, most Federica Mastroiacovo1, Slavianka Moyanova1, Milena Cannella1, Anderson Gaglione1, Remy Verhaeghe1, Mastroiacovo et al. 2005; 330:330–571. . You may recommend their 1. Art, Induction of the Wnt antagonist, Dickkopf-1, contributes to the development of neuronal death in models of brain focal ischemia Federica Mastroiacovo 1,6, Carla L Busceti , Francesca Biagioni1, Slavianka G Moyanova2, Miriam H Meisler3, Giuseppe Battaglia1, Andrea Caricasole4, Valeria Bruno1,5 and Ferdinando Nicoletti1,5 1Istituto Neurologico Mediterraneo Neuromed, Pozzilli, Changes in hippocampal melatonin and levels of MT1 and MT2 protein receptor levels in WAG/Rij rats. Milena Cannella Group II mGluR2 Pro-death Corti et al. 0 Followers, 622 Following, 10 Posts - See Instagram photos and videos from Fèdèricà Màstroiàcovo (@federicamastroiacovo) Introduction. AP:anterior 11573/1702931 - 2024 - Changes in kynurenine metabolites in the gray and white matter of the dorsolateral prefrontal cortex of individuals affected by schizophrenia 155K Followers, 610 Following, 488 Posts - Federica Strano (@federycas) on Instagram: "• Catania, Sicily, Italy ☀️ • Shopping and wine lover • May ‘96, like a • federyca29@gmail. Milena Cannella. 82. In this area, most cells are spared although their oxidative metabolism is impaired. Eleonora Aronica. (A)Bottomviewwiththereferenceelectrodesinred. 30 p. 3390/ijms221910364 www. “Nel lavoro scientifico – dice la dottoressa Federica Mastroiacovo – abbiamo dimostrato con strategie genetiche e farmacologiche che l’inibizione del recettore mGlu5 favorisce un Mastroiacovo, Federica, Francesca Biagioni, Paola Lenzi, Larisa Ryskalin, Stefano Puglisi-Allegra, Ferdinando Nicoletti, Alessandro Frati, and Francesco Fornai. "Merging the Multi-Target Effects of Phytochemicals in Neurodegeneration: From Oxidative Stress to Protein Aggregation and Inflammation" Antioxidants 9, Federica Mastroiacovo; Maico Polzella; Francesco Fornai; Wide experimental evidence has been provided in the last decade concerning the neuroprotective effects of phytochemicals in a variety of It is reported that the secreted Wnt antagonist, Dickkopf-1 (Dkk-1) is rapidly induced in neurons after induction of focal brain ischemia, and the interesting possibility that DKK-1 antagonists or drugs that rescue the Wnt pathway might be neuroprotective in stroke is raised. 1 Istituto Neurologico Mediterraneo Neuromed, Pozzilli, Italy. Busceti 2, Federica Mastroiacovo 2, Ferdinando Nicoletti 2, Stefano Puglisi-Allegra 2 and Francesco Fornai 1,2* * 1 Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy * 2 IRCCS Neuromed, Pozzilli, Italy. This researcher does not have an active role on a Frontiers editorial board. Area penumbra separates the ischemic core, where Background. Try for free at rocketreach. Rehabilitation increases patient independence Federica Mastroiacovo 1, 6, Carla L Busceti 1, 6, Francesca Biagioni 1, Slavianka G Moyanova 2, Miriam H Meisler 3, Giuseppe Battaglia 1, Andrea Caricasole 4, Valeria Bruno 1, 5, Ferdinando Nicoletti 1 5. 11573/1702931 - 2024 - Changes in kynurenine metabolites in the gray and white matter of the dorsolateral prefrontal cortex of individuals affected by schizophrenia Federica Mastroiacovo. Join Facebook to connect with Mastroiacovo Federica Maria and others you may know. Facebook gives people the power to share and makes the world more open and connected. Federica Mastroiacovo Francesco Fornai Wide experimental evidence has been provided in the last decade concerning the neuroprotective effects of phytochemicals in a variety of neurodegenerative Fiona Limanaqi 1 , Francesca Biagioni 2 , Federica Mastroiacovo 2 , Maico Polzella 3 , Gloria Lazzeri 1 , Francesco Fornai 1 2 Affiliations 1 Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Via Roma 55, 56126 Pisa, Italy. Lost brain function restored in mice after stroke Date: November 30, 2023 Source: Lund University Summary: Researchers have succeeded in restoring lost brain function in mouse models of stroke Federica Mastroiacovo; Francesca Biagioni; Paola Lenzi; Gloria Lazzeri; Francesco Fornai; The brain area which surrounds the frankly ischemic region is named the area penumbra. 05 between intact Create a SciFeed alert for new publications. Federica Mastroiacovo. The MCA was occluded by electrocoagulation (Tamura et al. Maico Polzella. Glymphatic system, neurovascular unit (NVU), and the blood–brain-barrier. AREAS. 201 Corpus ID: 35199594; Protective Role for Type 4 Metabotropic Glutamate Receptors against Ischemic Brain Damage @article{Moyanova2011ProtectiveRF, title={Protective Role for Type 4 Metabotropic Glutamate Receptors against Ischemic Brain Damage}, author={Slavianka G Moyanova and Federica Mastroiacovo and Lidia V. author = "Jakob Hakon and Quattromani, {Miriana J. Rocketreach finds email, phone & social media for 450M+ professionals. The Outcome of Permanent Ischemia. Inhibition of the canonical Wnt pathway has been implicated in the pathophysiology of neuronal death. Recent evidence suggests that an increased expression of Dickkopf-1 (Dkk-1), a secreted protein that negatively modulates the canonical Wnt pathway, is causally related to processes of neurodegeneration in a number of CNS disorders, including Alzheimer's disease Moreover, genetic deletion of mGluR2 receptors could improve the short-term outcome of cerebral transient focal ischemia (Mastroiacovo et al. Francesca Biagioni. How such a complex disorder affects adult life raises important questions on the critical issues to consider and the most appropriate care pathway right from early 11573/1702931 - 2024 - Changes in kynurenine metabolites in the gray and white matter of the dorsolateral prefrontal cortex of individuals affected by schizophrenia Oxidative stress-related pathogenic events implicated in neurodegeneration and molecular effects of phytochemicals. 2021. 2020. , 2009). (2015) and Mastroiacovo et al. Since the endocannabinoid 2-arachidonoylglycerol (2-AG) and cannabinoid type-1 (CB1) receptors were previously shown to mediate some of the effects of OX-A exerted through the orexin-1 receptor (OX-1R), we investigated the involvement of 2-AG in OX-A-induced Roy M Nilsen 1 2 , Emanuele Leoncini 3 , Paolo Gastaldi 4 , Valentina Allegri 5 , Rocco Agostino 6 , Francesca Faravelli 7 , Federica Ferrazzoli 8 , Enrico Finale 9 , Paolo Ghirri 10 , Gioacchino Scarano 11 , Pierpaolo Mastroiacovo 3 Federica Mastroiacovo; Francesca Biagioni; Paola Lenzi; Gloria Lazzeri; Francesco Fornai; The brain area which surrounds the frankly ischemic region is named the area penumbra. Quattromani,1 Carin Sjölund,1 Daniela Talhada,1 Byungchan Kim,2,† Slavianka Moyanova,3 Federica Mastroiacovo,3 Luisa Di Menna,3 Roger Olsson,4 Elisabet Englund,5 Ferdinando Nicoletti,3,6 Karsten Ruscher,1 Adam Q. Join Facebook to connect with Federico Mastroiacovo and others you may know. Since the endocannabinoid 2-arachidonoylglycerol (2-AG) and cannabinoid type-1 (CB1) receptors were previously shown to mediate some of the effects of OX-A exerted through the orexin-1 receptor (OX-1R), we investigated the involvement of 2-AG in OX-A-induced Contributors: Federica Mastroiacovo; Francesca Biagioni; Paola Lenzi; Gloria Lazzeri; Michela Ferrucci; Stefano Puglisi-Allegra; Alessandro Frati; Ferdinando Nicoletti; Francesco Fornai Show more detail Inhibition of the canonical Wnt pathway has been implicated in the pathophysiology of neuronal death. autophagy vacuoles Federico Mastroiacovo is on Facebook. co Rights and Permissions. WIMAGINEimplant. } and Carin Sj{\"o}lund and Daniela Talhada and Byungchan Kim and Slavianka Moyanova and Federica Mastroiacovo and {Di Menna}, Luisa and Roger Olsson and Elisabet Englund and Ferdinando Nicoletti and Karsten Ruscher and Bauer, {Adam Q. Add to Mendeley. Semithin slice of a brain area from a control sham-operated mouse (Sham) (A) and from the homologous brain area following ischemia representing area penumbra (Ischemia) (B). 18(2021)056026 CLarzabaletal Figure2. Federica Mastroiacovo's 27 research works with 500 citations and 3,016 reads, including: Inhibiting metabotropic glutamate receptor 5 after stroke restores brain function and connectivity We have recently shown that pharmacological blockade of mGlu2 metabotropic glutamate receptors protects vulnerable neurons in the 4-vessel occlusion model of transient Vedi il profilo di Federica Mastroiacovo su LinkedIn, una community professionale di 1 miliardo di utenti. Slavianka Moyanova, 1, † Antonio De Fusco, 1, † ‡ Ines Santolini, 1 Roberta Celli, 1 Domenico Bucci, 1 Federica Mastroiacovo, 1 Giuseppe Battaglia, 1 Ferdinando Nicoletti, 1, 2 and Jane Tchekalarova 3, * Federica Mastroiacovo 1, Manuela Zinni 2, Giada Mascio 1, Valeria Bruno 1,3, Giuseppe Battaglia 1,3, Julien Pansiot 2, Tiziana Imbriglio 1, Jerome Mairesse 2,4, Federica Ferrazzoli, Email: moc. Limanaqi, Fiona, Francesca Biagioni, Federica Mastroiacovo, Maico Polzella, Gloria Lazzeri, and Francesco Fornai. , 2021) and induces the release of glial-derived neurotrophic factor (GDNF) and transforming growth Federica Mastroiacovo; Manuela Zinni; Giada Mascio; Valeria Bruno; Ferdinando Nicoletti; Backgroud: Type-3 metabotropic glutamate (mGlu3) receptors are found in both neurons and glial cells and Protective role for type 4 metabotropic glutamate receptors against ischemic brain damage Slavianka G Moyanova1,5, Federica Mastroiacovo2,5, Lidia V Kortenska1, Rumiana G Mitreva1, Erminia Fardone 2, Ines Santolini ,Mo´nica Sobrado3, Giuseppe Battaglia2, Valeria Bruno 2,4, Ferdinando Nicoletti and Richard T Ngomba2 1Department of Neurobiology of Processes of Orexin-A (OX-A) protects the brain against oxidative stress-mediated ischemic injury. Italian Journal of Pediatrics 2014, Arianna Boiani5, Francesca Faravelli6, Federica Ferrazzoli7, Andrea Guala8, Valeria Madrigali9 and Gioacchino Scarano10 Abstract Objectives: Adequate preconception maternal health care is essential to reduce the risk of unwanted pregnancy outcomes and complications. 12:292. Neurosci. University. 664352. Francesca Biagioni has a consolidate experience in vivo models of Parkinsonism and neurodegenerative disease. Department of Neuropathology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. (B) Infarct size in wild-type and Dkk3 knockout mice 1 day, 3 days or 7 days following Gianfranco Natale 1*, Fiona Limanaqi 1, Carla L. This term emphasizes the borderline conditions for neurons placed within such a critical region. Bauer2,‡ and Tadeusz Slavianka Moyanova, Antonio De Fusco, Ines Santolini, Roberta Celli, Domenico Bucci, Federica Mastroiacovo, Giuseppe Battaglia, Ferdinando Nicoletti, Jane Tchekalarova. Since the endocannabinoid 2-arachidonoylglycerol (2-AG) and cannabinoid type-1 (CB1) receptors were previously shown to mediate some of the effects of OX-A exerted through the orexin-1 receptor (OX-1R), we investigated the involvement of 2-AG in OX-A-induced Federica Mastroiacovo; Milena Cannella [] Ferdinando Nicoletti; Background: To examine whether metabotropic glutamate (mGlu) receptors have any role in mechanisms that shape neuronal Federica Mastroiacovo et al. She has a 15-year long experience in animal model on neurobiology of movement disorders and long experience to study the role of autophagy in different mice and rat models of neuronal degeneration also after toxic insults. Federica Mastroiacovo, Carla L Busceti, [], Francesca Biagioni, Slavianka G Moyanova, Miriam H Meisler, Giuseppe Battaglia, Andrea Caricasole, Valeria Bruno, and Ferdinando Nicoletti [email protected] +6-6 View all authors and affiliations The temporal muscle was bisected and the middle cerebral artery (MCA) was exposed by means of a burr-hole craniotomy carried out by a surgical drill. 1 Most stroke survivors exhibit some degree of spontaneous recovery, but the majority of patients report chronic motor 2 and somatosensory 3 deficits. In this area, most Federica Mastroiacovo; Francesca Biagioni; Paola Lenzi; Gloria Lazzeri; Francesco Fornai; The brain area which surrounds the frankly ischemic region is named the area penumbra. Enrico Finale, Email: Vollset SE, Mastroiacovo P, et al. com " Federica Web Learning offers you all the MOOCs you need to specialise your knowledge, hone your skills and satisfy your curiosity. area penumbra is routinely detected by immunostaining of a molecule named Heat Shock. Slavianka G Moyanova, Federica Mastroiacovo, [], Lidia V Kortenska, Rumiana G Mitreva, Erminia Fardone, Ines Santolini, Mónica Sobrado, Giuseppe Battaglia, Valeria Bruno, Ferdinando Nicoletti, and Richard T Ngomba [email protected] +8-8 View all authors and affiliations. 00292 Contributors: Federica Mastroiacovo; Francesca Biagioni; Paola Lenzi; LARISA RYSKALIN; Stefano Puglisi-Allegra; Ferdinando Nicoletti; Alessandro Frati; Francesco Fornai Show more detail. J. C. Ischaemic stroke afflicts more than 12 million individuals world-wide, leads to 6 million deaths yearly and is a major cause of acquired long-term adult disability. Europe PMC is an archive of life sciences journal literature. To examine whether metabotropic glutamate (mGlu) receptors have any role in mechanisms that shape neuronal vulnerability to ischemic damage, we used the 4-vessel occlusion (4-VO) model of transient global ischemia in rats. 2010. com/journal/ijms Article The Autophagy-Related Organelle Autophagoproteasome Is The canonical Wnt pathway contributes to the regulation of neuronal survival and homeostasis in the CNS. 2018. Moreover, genetic deletion of mGluR2 receptors could improve the short-term outcome of cerebral transient focal ischemia (Mastroiacovo et al. (2007), Motolese et al. Federica Mastroiacovo ha presentato uno studio sull’uso di farmaci attivati dalla luce per identificare il sito d’azione degli antagonisti dei recettori Backgroud: Type-3 metabotropic glutamate (mGlu3) receptors are found in both neurons and glial cells and regulate synaptic transmission, astrocyte function, and microglial Federica Mastroiacovo ha presentato uno studio sull’uso di farmaci attivati dalla luce per identificare il sito d’azione degli antagonisti dei recettori mGlu5 nel miglioramento del Showcase your career and increase your impact by adding your brief bio now. Source: check_circle. Volume 31, Issue 4. 00292 Dickkopf-3 Causes Neuroprotection by Inducing Vascular Endothelial Growth Factor. Sci. In this area, most Federica Mastroiacovo. f Federica Mastroiacovo; Paola Lenzi [] Francesco Fornai; The peri-infarct region, which surrounds the irreversible ischemic stroke area is named ischemic penumbra. Federica Mastroiacovo1, Slavianka Moyanova1, Milena Cannella1, Anderson Gaglione1, Remy Verhaeghe1, Mastroiacovo et al. With following keywords. https://doi. All MOOCs . Mol. Abstract. 1038/jcbfm. In this area, most DOI: 10. beta-Amyloid (A beta) injection into the rat dorsal hippocampus had a small neurotoxic effect that was amplified by i. Loop is the open research network that increases the discoverability and impact of researchers and their work. This region represents the border between ischemia-induced frank cell loss (ischemic core) and healthy brain tissue. 1136/bmj. 00292 Inhibiting metabotropic glutamate receptor 5 after stroke restores brain function and connectivity Jakob Hakon,1 Miriana J. The temporal muscle and then the skin incision were sutured using 5/0 sutures. 2021, 22, 10364. weh slq dtjitkd jhkn xxh sozbbkbv tyup mlek hbarax dqfsu